产品货号：
Z36092
中文名称：
PMS2抗体
英文名称：
Anti-PMS2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-PMS2 Antibody |
| 指标别名 | PMS1 homolog 2;mismatch repair system component;HNPCC4;MLH4;MMRCS4CL;PMSL2;PMS2 |
| 克隆性 | Monoclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,IP,FCM |
| 基因名称 | PMS2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthesized peptide derived from human PMS2 |
| 实际分子量 | 120KD |
| 成分 | 500μg/mL;Rabbit IgG in phosphate buffered saline,pH7.4,150mM NaCl,0.02% sodium azide and 50% glycerol. |
| 纯化方式 | Affinity-chromatography |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Mismatch repair endonuclease PMS2 is an enzyme that in humans is encoded by the PMS2 gene.The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination.This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer.The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers,and is necessary for removal of the mismatched DNA.There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease.Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC;also known as Lynch syndrome) and Turcot syndrome. |
| Uniprot ID | P54278 |
| 基因名全称 | Mismatch repair endonuclease PMS2 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:20～100ICC/IF Immunocytochemistry/Immunofluorescence(ICC/IF) 1:20～100 Immunocoprecipitation 1:20 Flow cytometry (FCM) 1:20 |
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